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KMID : 0357920050390020091
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Korean Journal of Pathology
2005 Volume.39 No. 2 p.91 ~ p.98
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Expression of p63, bcl-2, bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin
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Zheng Zhen-Long
Kim Ae-Ree
Kye Young-Chul
Kim In-Sun
Zhang Xiang-Lan
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Abstract
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Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a reliable keratinocyte stem cell marker. Bcl-2 plays a key role in cell longevity by preventing apoptosis, whereas the bcl-6 gene functions as a transcriptional repressor. The p16-CDK4/6 complex arrests the cell cycle at G0/G1 phase. In the present study, the expression of p63, bcl-2, bcl-6, and p16 in BCC and SCC was evaluated.
Methods: Forty-seven BCCs and 43 SCCs were selected and microarrayed in paraffin blocks. Immunohistochemical analysis was performed with specific antibodies for bcl-2, bcl-6, p16 and p63.
Results: p63 was found to be expressed in all BCCs and SCCs. Bcl-2 was exclusively expressed in BCCs (100%), but there was negative expression in SCCs, whereas bcl-6 was positively expressed in 18.2% of SCCs, and was negative in BCCs. In SCCs, p16 was expressed at high frequency (47.7%) than in BCCs (14.9%). The expression of p16 was correlated with the histologic grades of SCCs.
Conclusion: The different patterns of bcl-2, bcl-6, p63 and p16 protein expression between BCCs and SCCs may represent the different histogenesis and morphologic features of two lesions.
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KEYWORD
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Carcinoma, Basal cell, Squamous cell, p63 protein, Proto-oncogene proteins bcl-2, Proto-oncogene protein bcl-6, Protein 16
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